No programming needed.
The only thing you have to do is to make sure the multiplex matches your car. For example you cant put an LX multiplex in an EX because the LX multiplex is missing some plug holes for things like sunroof, auto adjust seats, etc.
You can however go the other direction and put an EX multiplex into and SE (and probably even and LX). I know this cause I have done it with my SE and everything is working fine.